Latest technologies from Mount Sinai School of Medicinehttp://otbd.technologypublisher.comBe the first to know about the latest inventions and technologies available from Mount Sinai School of Medicineen-USSun, 21 Sep 2014 19:11:15 GMTSat, 22 Mar 2014 10:48:40 GMT 2014, Mount Sinai School of MedicineTreatment of Phelan-McDermid Syndrome and SHANK3 Mutations SHANK3 family of proteins plays a critical role in the functioning of synapses. Within synapses, the SHANK3 proteins act as scaffolds that connect neurons and influences dendrite spine maturation.  Hence, the SHANK3 gene is essential to the development of the human nervous system.  Phelan-McDermid Syndrome (PMS)—also called 22q13 Deletion Syndrome (22q13DS)—is a rare genetic syndrome in which one copy of the q13 portion of chromosome 22 is either missing or otherwise mutated. There is overwhelming evidence that it is the loss of one copy of the SHANK3 gene in this region is responsible for...Sat, 22 Mar 2014 10:48:40 GMTtechnology@mssm.edu COPYRIGHT No. TX7-713-909 - Autism Mental Status Examination, 11 Apr 2013 07:09:18 GMTtechnology@mssm.edu Molecule-Mediated Directed Cardiomyocyte Differentiation of Human Pluripotent Stem Cells ability to differentiate stem cells (human or pluripotent (iPS)) into cardiomyocytes offers not only valuable tools for research in cardiovascular development but potentially a path to cell therapy.  Current methods of differentiation into cardiomyocytes suffer from low yield and the hetergoneity in the derived cardiomyocytes.  In addition, inconsistencies in serum and other biomolecules and the high costs of growth factors prevent the current protocols from being scalable.   The research team at the Icahn School of Medicine at Mount Sinai led by Dr Roger Hajjar has devised a novel method ...Thu, 04 Apr 2013 08:35:50 GMTtechnology@mssm.edu Therapeutic Target for Heart Failure, 04 Apr 2013 06:12:54 GMTtechnology@mssm.edu Method To Isolate Pure Mitochondrial DNA, 22 Mar 2013 08:56:25 GMTtechnology@mssm.edu of mGluR Antatonists for Psychiatric Disorders Caused or Worsened by Cyfip1 Variations, 22 Mar 2013 08:53:07 GMTtechnology@mssm.edu of Acid Ceramidase For The Treatment of Lung Disease, 23 Jan 2013 06:16:01 GMTtechnology@mssm.edu for Programming Differentiated Cells Into Hematopoietic Stem Cells transplantation is the most common and successful example of stem cell therapy.  In patients with hematological disease, there continues to be a short supply of stem cells from bone marrow and umbilical cord blood because of the lack of sufficient number of immunologically compatible donors and the low number of hematopoietc stem cells (HSCs).  Direct programming of HSCs from differentiated cells from patients or suitable donors offers a method that overcomes existing limitations and provides an unlimited source of material for treatment.                  Professors Ihor Lemischk...Thu, 17 Jan 2013 05:09:26 GMTtechnology@mssm.edu Ceramidase as a Biomarker for Ovarian Cancer advances in cancer therapy, mortality of women with ovarian cancer has remained constant over the last 20 years.  In the US, ~23,000 women are diagnosed with ovarian cancer every year and ~13,000 deaths occur.  Of particular note is that the survival rate is less than 30% for those with Stage III cancer as opposed to 95% for Stage I diagnoses.  Therefore, early detection is crucial to successful recovery.  Currently, none of the existing serum biomarkers; e.g., CA 125 and CA 72-4, are reliable enough for accurate diagnosis of early stage ovarian cancer. Dr Edward Schuchman and his coll...Thu, 10 Jan 2013 11:58:05 GMTtechnology@mssm.edu